So what happens when you mix them together? The first thing to know: "Not everyone responds to alcohol and marijuana the same [way]," says Scott Lukas, a professor of psychiatry and pharmacology at Harvard Medical School. Lukas would know: He's now done two studies in which he got people high and observed their reactions. One study looked at how smoking weed affects the absorption of alcohol, and the other looked at how drinking alcohol affects the absorption of THC.
Smoking cannabis, he found, activates your body's cannabinoid 2 receptors CB2 , which can affect how quickly your body absorbs alcohol. But in the second study, Lukas found that alcohol actually has the inverse effect on THC: If you drink first and then smoke, it causes the levels of THC in your plasma to skyrocket, intensifying your high. That's because alcohol opens up blood vessels in your digestive system, which helps THC get absorbed—a finding confirmed in a more recent study done in While not life-threatening, the experience is not fun.
Your body switches back and forth between the parasympathetic and sympathetic nervous system, leaving you with chills, cold sweats, nausea, dizziness and repeated vomiting. And when in doubt, make sure you have access to a bathroom. THC can change how alcohol is metabolized in the body by pulling alcohol more slowly out of your GI tract.
Alcohol can also affect the brain , making it harder to discern whether you had too much to drink. Both Girodano and Volpicelli agree weed and alcohol can be safe to consume together when people take precautions to mitigate risk. One way is to stay hydrated. Throw in some pot and your risk of dehydration increases, especially if you vomit during a green out. Vice versa, using weed before drinking delays the effects of alcohol, potentially leading you to drink more than you should.
The increased alcohol intake increases the risk for toxicity. And if you get sick from smoking first and then drinking, the likelihood of vomiting is very low because weed also works as an antiemetic. Limiting the amount of alcohol consumed when crossfading could also help. Volpicelli says cannabis use can temporarily impair short-term memory, but chronic marijuana use lessens this over time because your body begins tolerating the effect.
But when you throw alcohol into the mix, the memory deficits can return and come back even stronger. By itself, excessive drinking increases the risk for alcohol dependency or alcoholism and has been linked to liver damage, kidney damage, heart problems and cognitive impairments.
Volpicelli says women are more susceptible than men to alcohol's physical effects. Consuming marijuana in ways other than smoking is probably fine: "While there aren't any studies on the effect of marijuana and Covid vaccine, it is unlikely to affect the immune response to vaccine," Yang said.
As for harder drugs like cocaine or ecstasy, Liu said we probably don't know enough to be able to say whether it is safe or not. If it's something you use recreationally, maybe just skip it that day, getting a vaccine is celebration enough," she said. The general consensus among experts is that when it comes to consuming marijuana or alcohol, moderation is key. If a person consumes these substances on a regular basis already, then pouring one out or rolling one up on the day of your vaccination, is probably fine.
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